Things to Know About Generic Tadalafil
Before we proceed any further looking into the effects, side effects, method and contraindications of Tadacip, we invite you to learn more about the formula behind the popular drug.
Tadalafil belongs to the class of PDE5i
There is a class of drugs called inhibitors of phosphodiesterase type 5, or PDE5. What is this substance and what is its role in erectile function? PDE5 is released first and foremost in the genitals, but also in the eye retina. The function of PDE5 is to make the walls of blood vessels rigid following ejaculation.
But when the enzyme build-up is not offset by another chemical, nitric oxide, a healthy erection cannot take place. The job of tadalafil and other inhibitors of PDE5 to create a setting where nitric oxide can be released in response to sexual stimulation, and in the absence of its counteragent, NO expands the blood vessels and facilitates the flow of the blood to the penis. The blood then gets “trapped” in the corpora cavernosa of the penis, and erection is sustained for as long as it is needed to have a full sexual act.
After ejaculation, the penis returns to the relaxed state as it would without the drug. This is what gives the effect of tadalafil its natural and discreet feeling.
The action of tadalafil spans 36 hours, which is 9 times longer than other drugs from its class. The effects of tadalafil are not inhibited or diminished with the simultaneous intake of meals, even those with high content of fat, according to the results of the study Tadalafil pharmacokinetics in healthy subjects by the researchers of Lilly Research Laboratories, Indianapolis, USA.
Tadalafil is used for conditions other than ED
The first PDE5 inhibitor, sildenafil, was discovered in the laboratory where a formula against PAH was being created. PAH (Pulmonary Arterial Hypertension) is a condition related to lungs health and insufficient saturation of the blood cells in the lungs. Tadalafil is approved for the use in patients with PAH, just like its counterpart sildenafil.
Tadalafil is also effective in prevention and supportive therapy of BPH (Benign Prostatic Hyperplasia). The improved circulation in the genitals promotes healthy nourishment of the tissues in the prostate.
Tadalafil generic is available internationally
As of March 2019, generic tadalafil became available from a vast number of manufacturers in all the countries. This date marked the end of the era for exclusive patent of tadalafil production. The price difference in some countries as a result between generic and brand tadalafil became significant. In the U.S., where the prices are uncontrolled by government, generic tadalafil cost is less, but not dramatically: it is 50% of the original drug cost, while generic tadalafil in other countries costs less than 12% of the original.
Potential and off-label uses of tadalafil
When a medicine has as much potential as the drugs from the PDE5i class, it is only a matter of time before they get approved for new uses. Off-label use is the application of a drug for the treatment of conditions that have not been approved yet, and require further research, but the anecdotal data shows the efficacy of such innovative treatment. In case of tadalafil, it is the treatment of Raynaud phenomenon (inflammatory disease affecting finger joint), mountain sickness, improving performance in athletes, relieving menstrual pain, heart disease and even brain health. PDE5 inhibitors are also sometimes used in the treatment of premature ejaculation.